Pulsomix | Non-Destructive Molecular Sampling

Core Capabilities

Longitudinal Sampling

Time-series analysis: Collect multiple samples from the exact same spot at different time points. Monitor tumor evolution and treatment response in real-time within the same model.

Spatial Mapping

Area-wide analysis: Collect a high density of samples from the same area simultaneously. Map molecular heterogeneity across the tissue interface with unprecedented precision.

High-Integrity Omics

Quality first: Achieve RIN scores ≥ 8.0. Extract pure RNA, proteins, and metabolites suitable for advanced NGS and Mass Spec analysis without mechanical degradation.

The "Snapshot" Problem

Blind Spots in Research

Current oncology research relies on destructive biopsies. Researchers get a single "snapshot" at the time of sacrifice, missing the critical dynamics of drug resistance.

Quality vs. Viability

Mechanical biopsies often destroy the sample or provide low yield. Researchers are forced to choose between high-quality data and keeping the model alive.

The Cost of Inefficiency

Longitudinal studies require massive cohorts because models are sacrificed at each point. This leads to high costs and biological "noise".

Reversible Electroporation

The Pulsomix Precision Bio-Sampler (PBS) leverages proprietary mild-pulse protocols to create transient pores in cell membranes. This allows internal molecules (RNA, proteins, lipids) to be extracted while maintaining cell viability and tissue structure.

≥ 8.0

RNA Integrity Number (RIN) Score

100%

Non-Destructive for Longitudinal Studies

The PBS Ecosystem

Hardware

Pulse Generator

The "brain" of the system. A reusable capital equipment featuring real-time impedance monitoring and adaptive waveform control for reproducible sampling across diverse tissue types.

Consumables

Micro-Electrode Arrays

Single-use, high-precision arrays designed for minimal invasiveness. Features integrated micro-fluidic collection for immediate stabilization of sensitive molecular profiles.

Software

AI-Driven Omics Analysis

Proprietary algorithms that translate raw molecular yields into actionable biological signatures, optimized for NGS and Mass Spec pipelines.

Applications

Oncology R&D

Monitor tumor response to therapy in real-time. Track the emergence of resistance markers in the same PDX model or organoid over weeks.

Advanced Biobanking

Standardized QC for tissue repositories. "Taste" the molecular profile of a sample before cryopreservation without compromising its integrity for future clinical use.

Non-Destructive Molecular Sampling